Daley is a security guard at The Museum of Natural History. He is handed an
over-sized flashlight and a dog-eared instruction manual, then left all alone in
the eerily quiet, cavernous museum. At his wit's end, Larry must recruit the
help of historical heavyweight Teddy Roosevelt just to survive the night.
Facing the possibility of losing his job and letting down his son Nick yet
again, Larry must wage an incredible battle to save the museum, hoping to
become at last the bold, adventurous dad he's always wanted to be. The man
who's been forever waiting for his moment of greatness just found it.
In New York, unemployed and divorced Larry Daley is a complete loser. His son Nick is very disappointed with his father who is going to be evicted. Larry accepts the job of night watchman in the Museum of Natural History and takes the place of three old security guards that have just retired in order to raise some money and pay his bills. On his first shift, Larry soon realizes that everything at the museum is not as it seems as the statues begin to come to life after the sun sets. The Museum transforms into complete chaos with the inexperienced Larry in charge as he learns that an old Egyptian stone that came to the Museum in 1950 brings these statues to life until dawn. When Larry brings his son to spend a night with him, the three old guards break into the Museum to try to steal the magical stone. Larry organizes all the historic characters to help him stop the criminals and save the museum.